Functional MRI in Frontal Lobe Syndromes

Project Outlines and Aims

We are conducting functional MRI scans on patients with frontal lobe dysfunction associated with the frontal variant of frontotemporal dementia (fvFTD) or Tourette’s syndrome (TS), as well as healthy control subjects. During scanning, participants observe video footage of various actions being performed and the response of the mirror neuron system (MNS) is compared across the groups. The observed actions consist of either hand/object related movements (e.g., a hand picking up a glass), body referred movements (e.g., an individual brushing their teeth) and control conditions. Patients also undergo formal neuropsychological assessment to determine their level of cognitive function.

This study will increase our knowledge of the neural mechanisms associated with fvFTD and TS. In particular, by comparing the response of the MNS in the patients and healthy control subjects, we will be able to provide insights into possible mechanisms underlying some of the behavioural (e.g., disinhibition, impulsivity) and cognitive changes commonly seen in these types of patients. This may in turn lead to improved understanding and management of these issues.

Potential Participants

We are interested in recruiting people with a diagnosis of frontal variant FTD or Tourette's syndrome, and healthy controls. You must be aged over 18. For the patient groups, you must have a diagnosis from a specialist who is willing to refer you to our clinic for further evaluation. Anyone who goes into the MRI scanner must be free from any metallic implants (e.g. pacemaker) and must not be claustrophobic.

Staff

Dr Ilana Hepner
Dr Melissa Slavin
Dr Wei Wen
Dr Mark Williams (Macquarie Centre for Cognitive Science)
Prof Perminder Sachdev